FURCHGOTT, ROBERT F.


FURCHGOTT, ROBERT F.
FURCHGOTT, ROBERT F. (1916– ), U.S. pharmacologist and Nobel Laureate in medicine. Furchgott was born in Charleston, South Carolina, and received his B.S. in chemistry at the University of North Carolina, Chapel Hill (1937), and his Ph.D. in biochemistry at Northwestern University, Chicago (1940). His first postdoctoral appointment was at Cornell University Medical School (1940–49), where he studied mediators of shock. He was assistant professor in the pharmacology department of Washington University, St Louis (1949–56), where he developed his lifelong interest in drug-receptor interactions, particularly in the adrenergic system which regulates blood vessel flow and smooth muscle tone. His experimental methods were largely based on rabbit aorta preparations. He was chairman of the new department of pharmacology at the State University of New York (now called the SUNY Health Science Center at Brooklyn; 1956–82), where his research work centered on the anomalous response of rabbit aortic preparations to drug and other stimuli, which often produced relaxation of the vessel instead of the expected contraction. This was attributable to the unsuspected release of a factor from the cells lining the internal surface of the preparation (called endothelial cells), which later proved to be nitric oxide (NO). This discovery followed meticulous analysis of a serendipitous observation and led to the award of the Nobel Prize (1994, jointly with Louis J. Ignarro and Ferid Murad). Wider roles for NO have now been identified, including defense against infection and blood pressure regulation. After retirement in 1989 Furchgott maintained active contacts in teaching and research with his former department and the pharmacology department of the University of Miami School of Medicine. His honors include the Gairdner Award (1991) and the Lasker Award for basic medical research. (Michael Denman (2nd ed.)

Encyclopedia Judaica. 1971.

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  • Furchgott, Robert F. — ▪ American scientist in full  Robert Francis Furchgott  born June 4, 1916, Charleston, S.C., U.S.       American pharmacologist who, along with Louis J. Ignarro (Ignarro, Louis J.) and Ferid Murad (Murad, Ferid), was co awarded the 1998 Nobel… …   Universalium

  • Furchgott , Robert F. — (1916–) American pharmacologist Furchgott was born in Charleston, South Carolina, and graduated with a BS in chemistry from the University of North Carolina in 1937. Three years later he gained his PhD in biochemistry at Northwestern University.… …   Scientists

  • Furchgott, Robert F(rancis) — born June 4, 1916, Charleston, S.C., U.S. U.S. pharmacologist. He received his Ph.D. from Northwestern University. With Louis J. Ignarro and Ferid Murad, he found that nitric oxide acts as a signaling molecule in the cardiovascular system.… …   Universalium

  • Furchgott, Robert F(rancis) — (n. 4 jun. 1916, Charleston, S.C., EE.UU.). Farmacólogo estadounidense. Obtuvo su Ph.D. en la Universidad de Northwestern. Junto con Louis J. Ignarro y Ferid Murad, descubrieron que el óxido nítrico actúa como molécula transmisora de señales en… …   Enciclopedia Universal

  • Furchgott — Robert F …   Scientists

  • Robert F. Furchgott — Robert Furchgott Robert Furchgott Robert Furchgott Naissance 4 juin 1916 Charleston (États Unis) …   Wikipédia en Français

  • Robert Francis Furchgott — Robert Furchgott Robert Furchgott Robert Furchgott Naissance 4 juin 1916 Charleston (États Unis) …   Wikipédia en Français

  • Robert Furchgott — Naissance 4 juin 1916 Charleston (États Unis) Décès 19 mai 2009 …   Wikipédia en Français

  • Robert Francis Furchgott — (* 4. Juni 1916 in Charleston, South Carolina; † 19. Mai 2009 in Seattle, Washington) war ein US amerikanischer Wissenschaftler. Nach dem Besuch der High School in Orangeburg studierte er zun …   Deutsch Wikipedia

  • Robert F. Furchgott — Robert Francis Furchgott (* 4. Juni 1916 in Charleston, South Carolina) ist ein US amerikanischer Wissenschaftler. Für seine Arbeiten über die Rolle von Stickstoffmonoxid als Botenstoff im Herz Kreislaufsystem erhielt Furchgott 1998 mit Louis J.… …   Deutsch Wikipedia


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